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Tirzepatide is a dual agonist that targets glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
The result showed that MO ethanol extract improved hyperglycemic and glucose tolerance at 30, 90, and 120 min after glucose (2.5 g/kg) solution gavage
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On the other hand, His 7 , Gly 10 , Asp 15 , and Phe 28 are critical for receptor activation, as their Ala substitutions resulted in a substantial decrease in cAMP production
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