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Additionally, ROS can promote the recruitment and activation of immunosuppressive cells, such as regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), which further inhibit the anti-tumor immune response and facilitate tumor progression [123]

474 Genitourinary dysfunction Genitourinary dysfunction in DAN encompasses both bladder dysfunction (diabetic cystopathy) and sexual dysfunction

10.1073/pnas.96.9.4820 67

Following fasting and calorie restriction, hormone insulin-like peptide 5 (INSL5) secreted by colonic L-cells is increased 56

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Cyanocobalamin is added as nutritional support, as B12 deficiency risk may increase with GLP-1-mediated dietary restriction and reduced intrinsic factor-dependent absorption