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Resistant disease was defined as regularly having more than one monthly attack on steady state of prophylactic treatment with Berotralstat or Lanadelumab or an inability to decrease frequency of biological prophylactic treatment with Lanadelumab from twice to once monthly due to breakthrough attacks

1998 Nov;139(5):552-61

While rare, some individuals may experience mild gastrointestinal discomfort

A probiotic effect observed in mice may not translate to humans, and the doses used in animal studies often do not scale linearly to human equivalents

Youre more likely to generate heat, which is lost as sweat, have faster kidney function, or burn more fat, all of which might cause thirst