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332 Currently, phase I trials have been completed to evaluate the efficacy of MEDI7247 in treating ASCT2-positive hematological malignancies and advanced solid tumors (NCT03106428

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However, other studies have confirmed that Ex-4 induces apoptosis in breast cancer cells by regulating genes associated with cell survival and the extrinsic apoptotic pathway [74]

Some individuals may experience mild reactions such as digestive discomfort or localized irritation at the injection site

The specificity of G6PD induced upregulation was attributed to increased histone hyperacetylation by histone acetyltransferases (HAT)s and increased HDAC, HAT, DNA polymerase II, and SP1 (transcription factor) binding to the G6PD core promoter (Figure 3)