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Dehydration affects muscle perfusion and electrolyte balance, creating conditions favorable for cramping

Insulin-independent mechanisms Altered glucose effectiveness In addition to insulin signaling, glucose tolerance is determined by glucose effectiveness (S G , mass-action effect of glucose), that is the ability of glucose per se to stimulate its own uptake and decrease endogenous glucose production

The injection site, technique, and frequency remain constant

If you suspect temperature compromise, inspect the lyophilized cake for discoloration or moisture

Average weight loss was 25 pounds

patients should discuss family planning with their clinician