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This was the aforementioned 12-week trial in HIV/AIDS patients with lipodystrophy that was discontinued, and its data were never published [9, 10]

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These proteins are implicated in mitosis, fatty acid metabolism, p53-dependent apoptosis and complex I of the mitochondrial respiratory chain, respectively ( Supplementary Table S1 )

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For most patients, these symptoms are mild to moderate, peak during the escalation phase, and gradually fade as tolerance develops