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The constant levels of marker proteins such as GAPDH, combined with observations indicating that knockdown of the UPR element, BiP/Grp78 , revealed no detectable effects on Nrf2, GCLC, or glutathione, further support the conclusion that NFT-mediated stabilization of Nrf2 is a major contributor to its accumulation and the subsequent stimulation of GCL and glutathione synthesis
Chen Y, Dong B, Jin X, Liu C, Zheng MH, Liang X, et al
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Lactate is a Preferential Oxidative Energy Substrate Over Glucose for Neurons in Culture
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