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The most commonly reported effects include nausea, bloating, and mild digestive discomfort, particularly during the early weeks of treatment as the body adjusts to the medication

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Importantly, Zepbound carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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Dosage depends on age, health condition, and the presence of additional illnesses