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Clinical trials (like the SURMOUNT-1 study) showed participants losing an average of 15% to 21% of their body weight over 72 weeks

Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice

More research is needed, but studies show that SSRIs arent always linked with weight gain

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All case series and reports 151,152,153,154,155 reported better metabolic outcomes in patients with comorbid severe mental illness and diabetes and/or obesity who were concomitantly treated with antipsychotics and GLP-1RAs