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Due to the disabling symptoms which include cognitive and physical impairment worsened by exertion (1517), there is a significant economic burden created by ME/CFS (18), and 3.3 billion annually in the U.K (19)

The surges of estrogen and progesterone that occur during pregnancy are thought to send the cells that produce melanin, called melanocytes, into overdrive

Nucleic Acids Res 52 , D368D375 (2024)

Moreover, M1-M have a peculiar metabolism, in which two breaks can be observed in the Krebs cycle, leading to citrate and succinate accumulation [6]

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Lauer AA, Grimm HS, Apel B, et al