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Persson C, Eaton A, Mayrovitz HN

Food and Drug Administration (FDA) in 2022 under the brand name Mounjaro, Tirzepatide represents a new class of diabetes treatment that works differently from traditional drugs

The maximum dose studied in clinical trials is 12 mg once weekly

Front Endocrinol (Lausanne) (2013) 4:166

In a double-blind, placebo-controlled, phase 2b trial, patients with diabetes were administered all doses of tirzepatide, dulaglutide, or placebo

Abbreviations CKD: Chronic kidney disease DKA: Diabetic ketoacidosis FDA: US Food and Drug Administration GLP-1 RA: Glucagon-like peptide-1 receptor agonist HCO: Healthcare organisation IHD: Ischaemic heart disease PSM: Propensity score matching SGLT2i: Sodium-glucose cotransporter 2 inhibitor SSMD: Strictly standardised mean difference UTI: Urinary tract infection References Gregory GA, Robinson TIG, Linklater SE et al (2022) Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study