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Early research on ferroptosis-characteristic cell death is dated back to the 1950s and 1960s, led by Harry Eagle who demonstrated that cysteine depletion reduced glutathione and led to cell death, whereas cysteine synthesis protected cell death by restoring glutathione [94,95,96]

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We find strong conservation across the animal kingdom of ER-localised GPX7, which may reflect its unique role of preventing oxidative damage during protein folding within the ER

PLoS One 7:e42277

10.1016/j.etap.2017.04.010 197 WangJ.DengX.ZhangF.ChenD.DingW

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