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Refrigeration slows this degradation to negligible levels, preserving the medication's intended therapeutic profile over the full shelf life, typically 12-24 months

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The overall data position orforglipron as a potentially more potent and user-friendly oral GLP-1 option, tightening its competitive grip in the cardiometabolic space.

The short answer is that it is physically possible to take both, and some doctors do prescribe them together off-label. Off-label means a doctor prescribes a medication for a purpose or in a combination that the FDA has not specifically approved

1C and 1D, Table S1)

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