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A Phase 2b 3-arm self-contained open-label controlled randomized trial is ongoing among healthy and Sm- and/or Sh-infected schoolchildren from the Senegal River Basin receiving a single dose of PZQ prior vaccination to further assess the safety and immunogenicity of Sm14/GLA-SE (NCT03799510) (113, 115)

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The investigators also demonstrated that hexosamines, N-acetylgalactosamine (GalNAc), and N-acetylglucosamine (GlcNAc) served as critical nitrogen sources in the mixed sugar medium

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Nitrogen oxides then start triggering chemical reactions