Syed S, Boland BS, Bourke LT, Chen LA, Churchill L, Dobes A, et al
HbA1c (glycated haemoglobin), which reflects average blood glucose over the preceding 23 months, typically shows measurable improvement by 1216 weeks
However, there are also some studies showed that some specific bacterial species can inhibit the section of endogenous GLP-1
GLP-1 receptor activation The GLP-1 component of retatrutide reduces appetite through multiple mechanisms: slowing gastric emptying (food stays in your stomach longer, so you feel full sooner), signaling satiety centers in the brain (your brain gets a stronger "stop eating" signal), and enhancing insulin secretion in response to meals
So it'll certainly be interesting to see what happens
You may have heard the term microdosing connected to certain psychedelic drugs