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Another study collected the blood samples of 45 patients with early-stage PD and 20 healthy controls to measure IL-1, IL-2, IL-6, IL-10, and TNF- levels, with significantly lower levels of IL-2 and IL-6 in the control group than those in PD patients (Kim et al., 2022)

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This triple mechanism, explained thoroughly in the GLP-3 (triple agonist) peptide guide , explains why retatrutide produced weight reduction of up to 24.2% at 48 weeks in phase 2 trials, numbers that exceeded both semaglutide and tirzepatide weight loss outcomes at similar timepoints