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A study in 49 people with knee osteoarthritis found that taking 3.4 grams of MSM per day for 12 weeks reduced pain and stiffness and improved physical function, compared to a placebo ( Additionally, it can enhance the effectiveness of other common supplements used to treat arthritis such as glucosamine sulfate, chondroitin sulfate and boswellic acid

Advances in Nutrition, 13 (6), 2180-2194

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ESPEN guideline on clinical nutrition in inflammatory bowel disease

However, no improvements in cognitive performance or retardation of cognitive decline have been observed (Rueda Revilla et al

In fact, there is no well-founded scientific evidence to prove its efficacy, and its skin-lightening claims currently hinge on individual case reports or anecdotal evidence