Reconstitution What you need Bacteriostatic water (BAC water) Insulin syringe (29-31 gauge, 0.5-1mL) Alcohol swabs Sterile vial of cagrilintide powder Sharps container for safe needle disposal Injection Route Subcutaneous injection once weekly Best sites Abdomen (2 inches away from navel) Front of thigh (middle third) Upper arm (outer area) Lower back area (above buttocks) Technique 1.Wash hands thoroughly and clean injection site with alcohol swab 2.Let the alcohol dry completely - this reduces stinging 3.Pinch the skin to create a fold for easier injection 4.Insert needle at a 45-90 degree angle depending on body composition 5.Inject the medication slowly over 5-10 seconds 6.Hold for 10 seconds before removing needle, then release skin Storage Signs of degradation Sample Daily Schedule Safety Is it safe
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Analysis of pooled data To increase the sample size and BW range, five independent experiments totalling 145 rats were pooled into vehicle (V, n = 38), drug (CS + C + S, n = 57) and calorie restriction (WM + PF, n = 50) groups (Extended Data Table 1)
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