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Interestingly, pretreatment with the GHSR inverse agonist SP-analog enhances 5-HT 2C intracellular receptor signaling, supporting the notion that inverse agonists of the GHSR (and perhaps antagonists) may augment the effectiveness of 5-HT 2C in the treatment of schizophrenia

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doi: 10.1186/s13024-019-0329-1