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Based on participants recollection of food noise before initiating semaglutide, mean FNQ score was 12.7 [95% confidence interval (CI) 12.313.1
Semaglutide Appetite Suppression vs
Tirzepatide Tirzepatide is a dual incretin receptor agonist designed to optimize metabolic outcomes through: 1
Second Natures peer-reviewed study published in JMIR Formative Research (2025) compared both medications within our programme: 3 Tirzepatide (Mounjaro) cohort (209 people): 22.1% average weight loss at 12 months 95.2% achieved at least 10% weight loss 83.7% achieved at least 15% weight loss Semaglutide (Wegovy) cohort (130 people): 17.1% average weight loss at 12 months 83.1% achieved at least 10% weight loss 56.2% achieved at least 15% weight loss Both cohorts exceeded clinical trial results, suggesting that comprehensive behavioural support enhances outcomes regardless of which medication you use
Default mode and frontoparietal network dynamics: Associations with familial risk for depression and stress sensitivity
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