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The available evidence suggests no increase in risk of major congenital malformations during pregnancy

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Patients escalate to 5mg at week 5, not by combining two 2.5mg pens but by switching to a 5mg pen

Additionally, in animal and clinical epilepsy-related research, increased levels of the NLRP3 inflammasome and neuroinflammatory cytokines have been detected in hippocampal tissues (15,16), suggesting their close association with epileptogenesis

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