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It has been shown that low-functional and non-functional SNVs in the UGT family genes can affect the dosage and concentration of VPA in the blood plasma and can be directly related to an increase in the blood level of its toxic metabolites and the development of ADRs
Scott et al., 1998), reduced adrenal size (Scott et al., 1999a
Briefly, 300 L reaction mixture was prepared by addition of 200 L of 0.1 M phosphate buffer (pH 6.5), 40 L of 1.5 mM l-tyrosine, 40 L of the selected compounds (101000 g/mL), 20 L of mh-Tyr (2000 U/mL) solution, and later incubated at 37 C for 10 min
Furthermore, the resonance energy transfer from tyrosine to tryptophan was very inefficient (Jones and Rumsby, 1975), suggesting that MBP is characterized by extended conformation
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