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Long-Term Considerations Long-term use of GH-releasing peptides has not been studied as extensively as synthetic HGH

Both exenatide and liraglutide are relatively well tolerated, with dose-dependent nausea, vomiting, and diarrhea being the most commonly reported adverse events observed in clinical trials

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5 Pathophysiology of DN DN is a multifaceted neurodegenerative disorder resulting from the interplay of metabolic, vascular, and neurodegenerative processes primarily driven by chronic hyperglycemia

In a phase 2 trial of obese subjects, cagrilintide used in different subcutaneous doses once weekly was associated with a mean weight loss of 6-10.8% after 26 weeks, compared with 9.0% with the glucagon-like 1 receptor (GLP-1R) liraglutide (3 mg/d) and 3% with placebo at 26 weeks