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In addition, mutations in ALDH7A1 in the lysine degradation pathway can also cause epilepsy that responds to P5P supplementation.[ref] Regulation of active B6: The cellular levels of P5P are fairly tightly regulated in the body with feedback loops and mechanisms in place

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James SJ, Melnyk S, Fuchs GJ, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW (2008) Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism

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"Molecular cloning, sequencing, and expression of human myocardial fatty acid ethyl ester synthase-III cDNA"