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Actually, the concentration of GSSG within control cells is more than two orders of magnitude lower than that of GSH, thus, usually, the measure of tGSH resembles that of GSH alone

The variability is the hallmark feature of sublingual delivery and the most consistent theme across user reports

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Given that the role of p53 in senescence regulation is complex, with both promoting and inhibitory effects depending on cell type and stress levels, manipulating the levels of p53 could have unwanted consequences