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The presence of these autoantibodies in both ME/CFS and Long COVID strongly suggests that for many patients, SFN is not just a static injury from a past infection, but an ongoing, active autoimmune disease that requires targeted immune modulation

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Furthermore, a 2-year, double-blind, randomized, placebo-controlled therapeutic trial in 158 healthy siblings of hyperhomocysteinemic patients with premature atherothrombotic disease folic acid plus vitamin B 6 treatment was associated with a decreased occurrence of abnormal exercise electrocardiography tests, which is consistent with a decreased risk of atherosclerotic events (Vermeulen et al, 2000)