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[22] [23] Patients experiencing severe or persistent gastrointestinal symptoms may benefit from temporarily holding the next dose or reducing to a previously tolerated dose

These include maintaining good sleep hygiene, engaging in moderate regular exercise (avoiding intense exercise close to bedtime), performing leg stretches or massage, applying hot or cold packs to the legs, and practicing relaxation techniques

After LPL hydrolyzes TRLs, sortilin, a member of the vacuolar protein sorting 10 (or VPS10) family, facilitates the uptake of secreted LPL and transfers it to endosomes in parenchymal cells, and LPL ends up in lysosomes for degradation [50,84]

They do not remove the need for medical monitoring

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Cisplatin-induced renal cell apoptosis: Caspase 3-dependent and -independent pathways