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It was found that more patients in the LIR group than the placebo group maintained their weight loss by 5%, which indicated that LIR 3.0 mg/d is expected to improve the maintenance of weight loss (93)

Treatment with oral semaglutide improves the fasting lipid level profile, as exploratory analysis resulted in a statistically superior reduction in total cholesterol [35, 38, 42], low-density lipoprotein (LDL) [35, 42], triacylglycerols (TAGs) [35, 38, 39], and very-low-density lipoprotein (VLDL) compared to the effects of placebo [38]

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it requires proper diet and regular physical activity

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This is particularly relevant for medications with narrow therapeutic windows like blood thinners, seizure medications, and certain antibiotics