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Rakipovski G, et al

Urinary excretion of homocysteine-thiolactone in humans

Frequently reported side effects include: Nausea Vomiting Diarrhea Constipation Stomach pain Reduced appetite Indigestion These symptoms are generally linked to the way GLP-1 drugs affect digestion and appetite regulation

Timeline: When Headaches Start and How Long They Last Most headaches related to semaglutide initiation occur within the first 13 weeks of starting therapy or after each dose increase during the titration phase

However, as a peptide drug, bivalirudin has a low exposure (AUC 0t = 23.7 nmol min mL 1 ) and a short half-life (t 1/2 = 15.1 min), with less than desirable pharmacokinetic properties

If you cannot tolerate the next dose increase, your clinician may keep you at your current dose for an additional week before progressing