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Notably, semaglutide treatment led to a reduction in heart weight, left ventricular mass, and wall thickness, indicating a reduction in cardiac hypertrophy ( Figure 1C )

Number of metabolites from each sample source associated with each ICA factor

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As demonstrated in vitro in cultured adipocytes (166, 167) and in vivo in Zucker rats (167), GIP enhances the activity of lipoprotein lipase (LPL), which promotes adipose tissue lipid disposal by enhancing hydrolytic cleavage of circulating triglycerides (TAG) into fatty acids (FA) and monoacylglycerol, which gets re-esterified and stored in adipose tissue

To learn more about some of these side effects, see the Side effects explained section later in this article

doi:10.1016/j.xops.2024.100547 23