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They rapidly raise blood B12 levels by bypassing the gut

Across remaining preclinical and animal studies, risk of bias was generally moderate, driven by small sample sizes, lack of explicit randomization or blinding, and indirectness to human metabolic outcomes

Mills and colleagues first identified the enzymes activity they observing the GPxs ability to shield hemoglobin from oxidative degradation [2]

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doi: 10.3389/fhort.2025.1727923 Received 18 October 2025 Revised 29 November 2025 Accepted 01 December 2025 Published 15 January 2026 Volume 4 - 2025 Edited by Marwa Moumni, Marche Polytechnic University, Italy Reviewed by Simone Piancatelli, Marche Polytechnic University, Italy Sarah M