Importantly, inhibition of EGFR, ERK, and c-Jun phosphorylation suppressed PD-L1 expression induced by glutamine deprivation, suggesting that glutamine deprivation upregulates PD-L1 expression on cancer cells through the EGFR/ERK/c-Jun pathway [168]
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Firstly, through a systematic review and network meta-analysis, researchers have assessed the effects of GLP-1R agonists on neuroinflammation and reported that, compared with placebo, GLP-1R agonists significantly reduce the levels of neuroinflammatory markers, such as TNF- and interleukin-1 (Urkon et al., 2025
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Verdict: Its possible
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