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A rat model study used lactacystin to target UPS to address synaptic plasticity in Alzheimers disease (AD), successfully restoring synaptic tagging and capture (STC) and impairing activity-dependent synaptic plasticity in vitro and associative long-term memory in vivo

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Patients transitioning to low-dose PT-141 after initial weight loss maintained their reduced body weight without significant regain, while those switching to placebo experienced rapid weight rebound

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