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doi: 10.1073/pnas.081620098

Chen H, Attieh ZK, Su T, Syed BA, Gao H, Alaeddine RM, et al

Patients deserve straight answers, not hype and not willful ignorance

Why no clinical drug development DSIP has not progressed through controlled clinical drug development, and the reasons map directly onto the issues discussed above: No identified receptor

Second, brain-mediated autonomic effects are exactly the kind of physiology that is subject to adaptation and counter-regulation over time, which is the mechanistic basis for the tachyphylaxis concern examined below

Estaki M, Pither J, Baumeister P, et al