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Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy

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The fixed modification included the aminomethylation of cysteine residues (57.0215 Da)

Choline deficiency can lead to fatty liver accumulation

A substudy published in Nature Medicine enrolled 98 participants with MASLD for 48 weeks (Nature Medicine, 2024): At 12 mg, 93% of participants with fatty liver achieved normal liver fat levels