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Within oligodendrocytes the OAA and acetyl-CoA serve to supply intermediates to the TCA cycle thereby, supporting energy production from the reduced electron carriers (NAHD and FADH 2 ) generated by the TCA cycle

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The group used cell-type-specific disruption of TrkB signalling in the indirect pathway spiny projection neurons (iSPNs), the cells most affected by HD in the early phase

The tissues were fixed in 4% paraformaldehyde and then embedded in paraffin