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Oxidative stress plays a central role in this melanocyte destruction, with elevated levels of ROS, such as HO, and deficiencies in key antioxidant enzymes creating a toxic environment for these cells

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It functions as a direct antioxidant through its thiol group, a substrate for glutathione peroxidase and glutathione S-transferase enzymes, and a regulator of protein function through S-glutathionylation

De Palma et al., 2014