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There are multiple potential predisposing/etiologic factors, including cancer itself, treatment-related adverse effects, physiologic complications, impaired performance status, and psychological comorbidities, such as depression [65, 67]

Its antioxidants protect against free radical damage, and DNA & RNA extracts rejuvenate the skin at a cellular level

This is particularly evident in the context of Louis-Bar syndrome, where neurodegeneration and other aging symptoms appear earlier than expected 157

10.7759/cureus.38263 45 JeyarajS.ShettyA

Still, new or persistent symptoms deserve a medical check to rule out other causes

Not all dark eye circles are due to fatigue