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Ketone bodies are known to be generated from acetyl-CoA when a large amount of acyl-CoA remains unmetabolised following the TCA cycle

and the potential for unmeasured confounding factors such as reasons underlying the decision to initiate GLP-1 RA therapy that could have influenced RA outcomes, they wrote

This part of the study may be the most clinically informative

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For tirzepatide, the starting dose is typically 2.5 mg weekly, increasing to 5 mg after four weeks, then 7.5 mg, 10 mg, 12.5 mg, and up to 15 mg

Biologically they are the same in terms of result just that they differ in terms of method of absorption