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Conclusions Although challenges associated with some of these compounds remain, important advances have been made in the development of safer and more effective drugs that could actually represent a breakthrough for fatal degenerative diseases such as ALS

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Funding This work was supported by Capacity Improvement Project of Xiyuan Hospital, China Academy of Chinese Medical Sciences (XYZX0303-03)

A multicenter trial of 390 patients with diabetes mellitus receiving insulin therapy who were randomized to receive metformin, 850 mg three times daily, or placebo assessed the risk of vitamin B 12 deficiency and low vitamin B 12 levels over four years

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Metab: Clin Exp 2001