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Additionally, Item 12 (whether the impact of risk of bias in individual primary studies on the meta-analysis results was assessed) also received relatively low scores

Lower concentrations (achieved by adding more water) make it easier to accurately measure very small microgram doses

CSF-derived cfDNA has recently been applied in clinical practice for analysis of BM, including being used to guide treatment decisions [46]

Some researchers inject daily with much lower doses (e.g., 1 to 2 mg per day instead of 7 mg weekly)

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