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Results: Age, gender, history of gastrointestinal disorders, and number of combined oral medications were found as risk factors for the occurrence of GISEs in patients with T2DM using GLP-1RAs ( p 0.05 for the validation set)

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Ongoing Phase 3 trials are evaluating retatrutide in knee osteoarthritis (where weight-independent anti-inflammatory effects have been observed), obstructive sleep apnea, and non-alcoholic steatohepatitis

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