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doi: 10.1097/NNR.0000000000000480

Follow-up appointments help track your progress and make any needed changes to your plan

10.1016/j.freeradbiomed.2020.08.009 86 LiQ.HanX.LanX.GaoY.WanJ.DurhamF.et al (2017a)

Any autoimmune symptom improvement would likely follow the timeline of significant weight loss and metabolic improvement, typically 12 to 24 weeks of treatment

STEP trials demonstrated dose-dependent weight loss with 2.4 mg weekly producing average reductions of 14.9% over 68-week periods

The mechanisms through which progestins exert their therapeutic effects are the anti-estrogenic effects, anti-vasculogenic action, induction of apoptotic cascade in endometriotic cells, suppression of inflammatory pathways (as production of metalloproteinases), cell proliferation suppression, and also anti-neurogenic effects with inhibition of nerve growth within endometriotic lesions [59, 63, 64]