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Opioids (heroin) predominantly target the brains reward system, leading to microglial activation and oxidative stress

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Among other cells, our immune system also consists of mast cells, which can release a wide variety of chemical mediators such as: Histamine Interleukins Prostaglandins Cytokines Chemokines When you are exposed to an allergen, toxin, and/or injury, these chemical mediators, especially histamine can be released into your body