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Future therapeutic approaches may involve: Microbiome-targeted therapies Gut-derived peptide treatments Personalized nutrition based on microbial composition These emerging strategies reflect a broader shift in metabolic medicine toward addressing root causes rather than simply managing symptoms

It gained particular prominence in studies examining the longevity and well-being of the people of Okinawa, recognized for having one of the highest life expectancies globally

Ethics statement The animal study was approved by Oujiang Laboratory Animal Ethics Committee

Foyer CH, Kunert K (2024) The ascorbate-glutathione cycle coming of age

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Though sulforaphane alone did not increase LC3-II levels, it blocked the significant decrease in LC3-II expression when co-administered with rotenone in vivo