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For MFS fold transporters, the intracellular gates are typically formed from TM4 and TM5 packing against TM10 and TM11, and the extracellular gates are formed by TM1 and TM2 packing against TM7 and TM8 that are symmetry related pairs of transmembrane helices 52

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Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance

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Truncation studies showed that the membrane proximal 61 amino acids of GP130 are sufficient for signal transduction (68), and later it was shown for GHR that the membrane proximal 20 residues (which includes the Box1 motif) of the ICD is sufficient for JAK2 binding, but not sufficient for GH-induced activation of JAK2 (69)