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It can be found that compared with the Model group, the Low group and High group secreted more insulin after berberine treatment (Figure 1I), and calculated homeostatic model assessment of insulin resistance (HOMA-IR) index according to the following formula: HOMA-IR = FBG (mM) Fasting insulin (mU/L)/22.5 (Figure 1J)

The result is reduced potency and potentially altered pharmacokinetics

Not all drugs can be given intramuscularly, for example, phenytoin

The appropriate concentration depends entirely on the laboratory protocol, measurement precision required, and experimental design

doi: 10.1007/s00406-006-1004-4 42