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Description

The point about sustainability is a good one

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In addition, the absence of key study design features, such as control groups or randomization, limits the ability to draw firm conclusions about cause and effect

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Notably, controlled fluid flow introduces sustained perfusion and physiologically relevant shear forces, both of which modulate cellular behaviour and allow for a more accurate assessment of nanoparticle transport, distribution and cellular uptake than static in vitro models [175, 176]

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Dart RC, Mullins ME, Matoushek T, Ruha AM, Burns MM, Simone K, et al

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