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26,27 Suggestive evidence of hemoglobin A1c-lowering being the cause of the reported worsening with GLP-1/GIP agonists can be derived by comparing the results of two recent retrospective cohort studies assessing retinopathy outcomes between subjects treated with GLP-1/GIP agonists and sodium-glucose cotransporter-2 (SGLT2) inhibitors

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The promotion of cancer development by GLP-1RAs Several studies have reported a potential association between GLP-1RA use and increased thyroid cancer risk, although no causal relationship has been definitively established [1]

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