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Historically, glucagon signaling is associated with raising blood glucose, but in the triple-agonist concept this potentially unfavorable effect is expected to be balanced by the simultaneous incretin stimulation of glucose-dependent insulin secretion

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I think this is an overblown concern

Lipid parameters, fasting glucose and hsCRP were log-transformed before fitting the MMRM, as described in the SAP

doi: 10.1210/en.2012-1983 137 Candelario-JalilEGonzlez-FalcnAGarca-CabreraMAlvarezDAl-DalainSMartnezGet al

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